abstract：:Obstetric hemorrhage is often a sudden, life-threatening event. Successful management hinges on both preoperative preparation if hemorrhage is anticipated as well as knowledge of interventions. Uterine-sparing techniques, such as aggressive and early use of uterotonics, balloon tamponade, uterine compression sutures, ...

journal_title：Seminars in perinatology

authors： Shah M,Wright JD

更新日期：2009-04-01 00:00:00

abstract：:Fetal and neonatal alloimmune thrombocytopenia is not a well-known disease, except among specialists in maternal-fetal medicine, neonatologists, and certain pediatricians (ie, hematologists). However, this is by far the most common cause of early severe thrombocytopenia in neonates and of intracranial hemorrhage in te...

journal_title：Seminars in perinatology

authors： Bussel JB,Sola-Visner M

更新日期：2009-02-01 00:00:00

abstract：:Thyroid hormone plays an important role in regulating cardiovascular function during the transition to extrauterine physiology. Multiple mechanisms participate, ranging from transcriptional to more immediate nongenomic modes of regulation. ...

journal_title：Seminars in perinatology

authors： Portman MA

更新日期：2008-12-01 00:00:00

abstract：:Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contrib...

journal_title：Seminars in perinatology

authors： Guttentag S

更新日期：2008-10-01 00:00:00

abstract：:The principal objective of antenatal testing is to detect fetal hypoxia before the fetus has suffered lasting harm. This article summarizes some of the mechanisms by which fetal oxygen consumption is maintained under normal conditions, and adaptations that occur in response to hypoxemia. Alterations in the fetal heart...

journal_title：Seminars in perinatology

authors： Martin CB Jr

更新日期：2008-08-01 00:00:00

abstract：:The complex nature of amniotic fluid reflects contributions from many fetal systems, many functional roles, and multiple interactions with fetal maturation, obstetric, and maternal factors. Simple ultrasound measurement, probably done best with the maximum vertical pocket method, has a clinical role in fetal surveilla...

journal_title：Seminars in perinatology

authors： Harman CR

更新日期：2008-08-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR), which complicates approximately 3% to 10% of all pregnancies leads to preferential hemodynamic changes in affected fetuses. Advanced ultrasound modalities allow reliable and reproducible assessment of the intrauterine fetal cardiac function. Among other methods, combined cardiac...

journal_title：Seminars in perinatology

authors： Bahtiyar MO,Copel JA

更新日期：2008-06-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit. Here we review the epidemiology and pathophysiology of NEC, with an emphasis on the latest research findings and potential areas for future research. NEC continues to be one of the most deva...

journal_title：Seminars in perinatology

authors： Lin PW,Nasr TR,Stoll BJ

更新日期：2008-04-01 00:00:00

abstract：:A large body of research indicates that children born very preterm are at increased risk for neurobehavioral impairments; however, research examining outcome for extremely preterm (EP) children is limited. This chapter will review the literature focusing on early development delay, general intellectual functioning, sp...

journal_title：Seminars in perinatology

authors： Anderson PJ,Doyle LW

更新日期：2008-02-01 00:00:00

abstract：:Transplant recipients are becoming pregnant with increasing frequency, and successful pregnancy outcomes have now been reported for women with all types of solid organ transplants. To prevent rejection of the transplanted organ, these patients are maintained on a life-long immunosuppressive regimen that must also be c...

journal_title：Seminars in perinatology

authors： Fuchs KM,Coustan DR

更新日期：2007-12-01 00:00:00

abstract：:Adverse pregnancy outcome from environmental factors may include congenital anomalies, increased risk for miscarriage, preterm delivery, intrauterine growth restriction, and still birth. Apart from adverse pregnancy outcome, there may be effects on the other reproductive functions, like menstrual disorders and inferti...

journal_title：Seminars in perinatology

authors： Triche EW,Hossain N

更新日期：2007-08-01 00:00:00

abstract：:Among risk factors for shoulder dystocia, a prior history of delivery complicated by shoulder dystocia is the single greatest risk factor for shoulder dystocia occurrence, with odds ratios 7 to 10 times that of the general population. Recurrence rates have been reported to be as high as 16%. Whereas prevention of shou...

journal_title：Seminars in perinatology

authors： Gurewitsch ED,Johnson TL,Allen RH

更新日期：2007-06-01 00:00:00

abstract：:In initiating enteral feedings for high-risk infants, clinicians struggle with three fundamental questions: When should enteral feedings be initiated? Should a period of trophic (minimal) feeding be provided? When feedings are advanced, how rapidly should the volume be increased? We present the findings of our systema...

journal_title：Seminars in perinatology

authors： Tyson JE,Kennedy KA,Lucke JF,Pedroza C

更新日期：2007-04-01 00:00:00

abstract：:Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. New genes may be inserted in mice, specific genes inactivated or "knocked out," and more complex animals created in which genes can be turned on or off at different times in development or in different tissues. These...

journal_title：Seminars in perinatology

authors： Glasser SW,Nogee LM

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:The purpose of this analysis was to determine the impact on specific forms of neonatal morbidity and mortality by allowing women to opt for delivery by elective cesarean section at 39 weeks of gestation (EGA). According to the National Vital Statistics Reports, over 70% of deliveries in the U.S. annually are at...

journal_title：Seminars in perinatology

authors： Hankins GD,Clark SM,Munn MB

更新日期：2006-10-01 00:00:00

abstract：:Nutrition plays a critical role in the prevention and management of bronchopulmonary dysplasia (BPD). Growth failure in infants with BPD is predominantly due to malnutrition. Malnutrition can worsen BPD by compromising lung growth. Feeding difficulties in these infants can further affect nutrition. Dexamethasone, used...

journal_title：Seminars in perinatology

authors： Biniwale MA,Ehrenkranz RA

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Pulmonary inflammation, increased production of the inflammatory cytokine interleukin-1beta (IL-1beta), and vitamin A deficiency are risk factors for the development of bronchopulmonary dysplasia (BPD) in premature infants. To determine the mechanisms by which IL-1beta influences lung development, we have ge...

journal_title：Seminars in perinatology

authors： Bry K,Lappalainen U

更新日期：2006-06-01 00:00:00

abstract：:Late preterm infants (34-37 weeks postmenstrual age at birth) are intermediate between less mature preterm infants and infants born at 38 weeks or more in regard to autonomic brain stem maturation. Ventilatory responses to CO(2) in preterm infants born at 33 to 36 week are significantly higher than in infants born at ...

journal_title：Seminars in perinatology

authors： Hunt CE

更新日期：2006-04-01 00:00:00

abstract：:Late preterm infants (34-37 weeks gestation) pose unique challenges to physicians and nurses involved in their care after birth. They may be cared for in different units within hospitals after birth, including Neonatal Intensive Care Units, Newborn Nurseries, or rooming in with the mother. As a result of their gestati...

journal_title：Seminars in perinatology

authors： Laptook A,Jackson GL

更新日期：2006-02-01 00:00:00

abstract：:Nuchal translucency (NT) describes an echo-free area, below the skin, in the posterior nuchal and back region of the fetus and is typically observed in the first and early second trimester of pregnancy. A wide NT has been correlated with chromosomal and congenital abnormalities in the fetus. An accurate NT measurement...

journal_title：Seminars in perinatology

authors： Abuhamad A

更新日期：2005-12-01 00:00:00

abstract：:The incidence of twins, triplets, and high-order multiples has increased dramatically in the last two decades secondary to greater reliance on fertility treatments and to delayed childbearing. Offspring of a multiple gestation are at increased risk for both chromosomal and structural abnormalities. Prenatal diagnosis ...

journal_title：Seminars in perinatology

authors： Cleary-Goldman J,D'Alton ME,Berkowitz RL

更新日期：2005-10-01 00:00:00

abstract：:The genetic sonogram is a composite algorithm combining multiple individual markers to increase Down syndrome risk prediction. Transformation of sonographic information into a standard mathematical format represented an early challenge that has now been surmounted. Using increasingly sophisticated mathematical techniq...

journal_title：Seminars in perinatology

authors： Bahado-Singh RO,Oz UA,Mendilcioglu I,Mahoney MJ

更新日期：2005-08-01 00:00:00

abstract：:Down syndrome (DS) screening has been an integral part of routine prenatal screening for the last three decades. Recent efforts have been directed at developing additional non-invasive prenatal screening techniques that could not only improve sensitivity of prenatal screening, but also be employed in the first trimest...

journal_title：Seminars in perinatology

authors： Fuchs KM,Peipert JF

更新日期：2005-08-01 00:00:00

abstract：:This article presents an overview of current topics related to the genetics of hearing loss. The review focuses on the approach toward a child with a sensorineural hearing loss of unknown etiology and the incorporation of genetic testing into the workup. Nongenetic causes of hearing loss are reviewed, as they are impo...

journal_title：Seminars in perinatology

authors： Rehm HL

更新日期：2005-06-01 00:00:00

abstract：:Many infants with CDH can be managed with conventional mechanical ventilation and pharmacotherapy. However, some infants will require levels of ventilator support that are not compatible with survival. In these circumstances, extracorporeal membrane oxygenation (ECMO) has been used with varying results. The indication...

journal_title：Seminars in perinatology

authors： Khan AM,Lally KP

更新日期：2005-04-01 00:00:00

abstract：:Although initially designed for respiratory failure, venoarterial extracorporeal membrane oxygenation (VA ECMO) has become a mainstay of therapy in the treatment of patients with congenital heart disease, providing preoperative and postoperative support for infants with temporary impairment of myocardial function. Pos...

journal_title：Seminars in perinatology

authors： Hines MH

更新日期：2005-02-01 00:00:00

abstract：:The primary methods currently in use for imaging the infant brain are cranial ultrasound (CUS), computed tomography (CT) and magnetic resonance imaging (MRI). This review outlines the relative strengths and weaknesses of these modalities in relation to the premature infant, with specific focus on the correlations betw...

journal_title：Seminars in perinatology

authors： Neil JJ,Inder TE

更新日期：2004-12-01 00:00:00

abstract：:Long-term sequelae of preterm birth have been studied extensively up until the age of 5 to 8 years. However, the cognitive development of adolescents born preterm has received limited attention. The objective of this study is to determine school performance in adolescents born very preterm. We have followed up a cohor...

journal_title：Seminars in perinatology

authors： van de Bor M,den Ouden L

更新日期：2004-08-01 00:00:00

abstract：:Minimally invasive surgery has been one of the most important surgical advances in the last 15 years. The development of smaller instruments has allowed pediatric surgeons to apply this rapidly evolving technology to neonates. Congenital neonatal deformities including tracheoesophageal fistula, patent ductus arteriosu...

journal_title：Seminars in perinatology

authors： Georgeson KE,Robertson DJ

更新日期：2004-06-01 00:00:00

abstract：:Acute renal failure in the newborn is a common problem and is typically classified as prerenal, intrinsic renal disease including vascular insults, and obstructive uropathy. In the newborn, renal failure may have a prenatal onset in congenital diseases such as renal dysplasia with or without obstructive uropathy and i...

journal_title：Seminars in perinatology

authors： Andreoli SP

更新日期：2004-04-01 00:00:00

abstract：:Accurate assessment of fetal growth status requires the definition of an optimal standard, which represents the growth potential of the baby. Against this standard, individually 'customized' percentiles can be calculated. They improve the distinction between normal and abnormal, and help in our understanding and diagn...

journal_title：Seminars in perinatology

authors： Gardosi J

更新日期：2004-02-01 00:00:00

abstract：:Candida is a leading cause of late onset infection (> 3 days of age) in the premature infant. Therefore, decisions about the diagnosis and management of infections caused by Candida are commonplace in the neonatal intensive care unit. Despite this fact, there are few comparative trials about treatment of neonatal Cand...

journal_title：Seminars in perinatology

authors： Bliss JM,Wellington M,Gigliotti F

更新日期：2003-10-01 00:00:00

abstract：:Infection is a serious complication among very low birth weight (VLBW) preterm infants hospitalized in neonatal intensive care units. This article reviews studies from the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network including infection data from observational studies and ...

journal_title：Seminars in perinatology

authors： Stoll BJ,Hansen N

更新日期：2003-08-01 00:00:00

abstract：:Clinically silent upper genital tract microbial infections have been strongly associated with spontaneous preterm delivery, especially prior to 32 weeks gestational age. This condition represents a potentially preventable or reversible cause of preterm birth using safe, readily available, and inexpensive antibiotics. ...

journal_title：Seminars in perinatology

authors： Andrews WW,Goldenberg RL,National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

更新日期：2003-06-01 00:00:00

abstract：:Experience gathered over the last decade from high-risk centers provide strong evidence that mid-trimester sonographic markers are sensitive for Down syndrome prediction. More recent data indicate that combining mid trimester sonography with traditional serum markers significantly improves diagnostic accuracy over eit...

journal_title：Seminars in perinatology

authors： Bahado-Singh R,Cheng CC,Matta P,Small M,Mahoney MJ

更新日期：2003-04-01 00:00:00

abstract：:The safety of cesarean section has improved dramatically over the past 50 years. During the past 20 years a greater awareness of and discussion about the symptomatic morbidity that can result for women following vaginal delivery has occurred and women's expectations for the outcome of pregnancy for them and their babi...

journal_title：Seminars in perinatology

authors： Morrison J,MacKenzie IZ

更新日期：2003-02-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are frequently used during pregnancy (premature labor, polyhydramnios) and the immediate postnatal period (closure of patent ductus arteriosus). This article evaluates the renal effect of 3 nonspecific COX inhibitors (aspirin, indomethacin, and ibuprofen) in newborn rabbits. Five g...

journal_title：Seminars in perinatology

authors： Guignard JP

更新日期：2002-12-01 00:00:00

abstract：:The use of broad spectrum antimicrobials, the emergence of multiresistant organisms, and the hospital drug costs associated with antimicrobials have all driven the need for institutions to develop strategies to control the use of antimicrobials. Formulary restrictions, prior approval mechanisms, treatment guidelines, ...

journal_title：Seminars in perinatology

authors： Kubin CJ

更新日期：2002-10-01 00:00:00

abstract：:This review documents and assesses recent trends in sudden infant death syndrome. We review medical literature, Internet resources, and national governmental data. A striking reduction in SIDS incidence of more than 50% has been observed in various countries after interventions, particularly during the early 1990s, to...

journal_title：Seminars in perinatology

authors： Ponsonby AL,Dwyer T,Cochrane J

更新日期：2002-08-01 00:00:00

abstract：:Poorly controlled maternal diabetes in pregnancy may delay fetal pulmonary maturation. However, diabetic women with good glycemic control have fetal lung maturation at the same gestational age as nondiabetic women. With modern ultrasound technology, gestational dates can be accurately assessed in the first or early se...

journal_title：Seminars in perinatology

authors： Piper JM

更新日期：2002-06-01 00:00:00